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Miconazole enhances nerve regeneration and functional recovery after sciatic nerve crush injury.
- Source :
- Muscle & Nerve; May2018, Vol. 57 Issue 5, p821-828, 8p
- Publication Year :
- 2018
-
Abstract
- <bold>Introduction: </bold>Improving axonal outgrowth and remyelination is crucial for peripheral nerve regeneration. Miconazole appears to enhance remyelination in the central nervous system. In this study we assess the effect of miconazole on axonal regeneration using a sciatic nerve crush injury model in rats.<bold>Methods: </bold>Fifty Sprague-Dawley rats were divided into control and miconazole groups. Nerve regeneration and myelination were determined using histological and electrophysiological assessment. Evaluation of sensory and motor recovery was performed using the pinprick assay and sciatic functional index. The Cell Counting Kit-8 assay and Western blotting were used to assess the proliferation and neurotrophic expression of RSC 96 Schwann cells.<bold>Results: </bold>Miconazole promoted axonal regrowth, increased myelinated nerve fibers, improved sensory recovery and walking behavior, enhanced stimulated amplitude and nerve conduction velocity, and elevated proliferation and neurotrophic expression of RSC 96 Schwann cells.<bold>Discussion: </bold>Miconazole was beneficial for nerve regeneration and functional recovery after peripheral nerve injury. Muscle Nerve 57: 821-828, 2018. [ABSTRACT FROM AUTHOR]
- Subjects :
- ENZYME inhibitors
MICONAZOLE
ACTION potentials
ANIMAL experimentation
BIOLOGICAL models
CELL physiology
CELLS
COMPARATIVE studies
CONVALESCENCE
CYTOKINES
RESEARCH methodology
MEDICAL cooperation
NERVE tissue proteins
PERIPHERAL nervous system
NERVOUS system regeneration
NEURAL conduction
NEURONS
RATS
RESEARCH
SCIATICA
CYTOMETRY
EVALUATION research
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 0148639X
- Volume :
- 57
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Muscle & Nerve
- Publication Type :
- Academic Journal
- Accession number :
- 129210004
- Full Text :
- https://doi.org/10.1002/mus.26033