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Memory vs memory‐like: The different facets of CD8+ T‐cell memory in HCV infection.
- Source :
- Immunological Reviews; May2018, Vol. 283 Issue 1, p232-237, 6p
- Publication Year :
- 2018
-
Abstract
- Summary: Memory CD8<superscript>+</superscript> T cells are essential in orchestrating protection from re‐infection. Hallmarks of virus‐specific memory CD8<superscript>+</superscript> T cells are the capacity to mount recall responses with rapid induction of effector cell function and antigen‐independent survival. Growing evidence reveals that even chronic infection does not preclude virus‐specific CD8<superscript>+</superscript> T‐cell memory formation. However, whether this kind of CD8<superscript>+</superscript> T‐cell memory that is established during chronic infection is indeed functional and provides protection from re‐infection is still unclear. Human chronic hepatitis C virus infection represents a unique model system to study virus‐specific CD8<superscript>+</superscript> T‐cell memory formation during and after cessation of persisting antigen stimulation. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEPATITIS C virus
CD8 antigen
T cells
IMMUNOLOGIC memory
IMMUNOLOGICAL adjuvants
Subjects
Details
- Language :
- English
- ISSN :
- 01052896
- Volume :
- 283
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunological Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 129134709
- Full Text :
- https://doi.org/10.1111/imr.12642