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Anticancer Activity of Tamoxifen Loaded Tyrosine Decorated Biocompatible Fe3O4 Magnetic Nanoparticles Against Breast Cancer Cell Lines.
- Source :
- Journal of Inorganic & Organometallic Polymers & Materials; May2018, Vol. 28 Issue 3, p1178-1186, 9p
- Publication Year :
- 2018
-
Abstract
- Abstract: In this work we reported the synthesis of tamoxifen (TMX) loaded l-tyrosine natural amino acids (Tyr) modified Fe<subscript>3</subscript>O<subscript>4</subscript> magnetic nanoparticles. Tyr, which was containing phenol groups was selected to study their effects on biocompatibility, loading capacity and release profile of TMX. TMX loaded Tyr modified Fe<subscript>3</subscript>O<subscript>4</subscript> magnetic nanoparticles (F@Tyr@TMX NPs) were characterized by X-ray diffraction, thermo gravimetric analysis, Fourier transform infrared spectroscopy, vibrating sample magnetometer, dynamic light scattering and transmission electron microscopy techniques. The results showed that the ζ-potential of F@Tyr@TMX NPs was about − 12.8 mV and the average size was 22.19 ± 3.58 [mean ± SD (n = 50)] nm. The loading capacity of 11.34 ± 0.09% and encapsulation efficiency of 51.21 ± 0.41%. Additionally, hemolysis test and MTT assays on HEK-293 were performed for determination of biocompatibility of F@Tyr@TMX NPs. Finally, the anticancer activity of F@Tyr@TMX NPs studied on MCF-7 breast cancer cell lines. The results indicate that these as prepared magnetic nanoparticles are suitable for delivery of TMX and even other hydrophobic drugs.Graphical Abstract: <graphic></graphic> [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15741443
- Volume :
- 28
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Inorganic & Organometallic Polymers & Materials
- Publication Type :
- Academic Journal
- Accession number :
- 129111459
- Full Text :
- https://doi.org/10.1007/s10904-017-0758-7