Back to Search
Start Over
Prebiopsy multiparametric MRI-based risk score for predicting prostate cancer in biopsy-naive men with prostate-specific antigen between 4-10 ng/mL.
- Source :
- Journal of Magnetic Resonance Imaging; May2018, Vol. 47 Issue 5, p1227-1236, 10p
- Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>Risk calculators have traditionally utilized serum prostate-specific antigen (PSA) values in addition to clinical variables to predict the likelihood of prostate cancer (PCa).<bold>Purpose: </bold>To develop a prebiopsy multiparametric MRI (mpMRI)-based risk score (RS) and a statistical equation for predicting the risk of PCa in biopsy-naive men with serum PSA between 4-10 ng/mL that may help reduce unnecessary biopsies.<bold>Study Type: </bold>Prospective cross-sectional study.<bold>Subjects: </bold>In all, 137 consecutive men with PSA between 4-10 ng/mL underwent prebiopsy mpMRI (diffusion-weighted [DW]-MRI and MR spectroscopic imaging [MRSI]) during 2009-2015 were recruited for this study.<bold>Field Strength/sequence: </bold>1.5T (Avanto, Siemens Health Care, Erlangen, Germany); T1 -weighted, T2 -weighted, DW-MRI, and MRSI sequences were used.<bold>Assessment: </bold>All eligible patients underwent mpMRI-directed, cognitive-fusion transrectal ultrasound (TRUS)-guided biopsies.<bold>Statistical Tests: </bold>An equation model and an RS were developed using receiver operating characteristic (ROC) curve analysis and a multivariable logistic regression approach. A 10-fold crossvalidation and simulation analyses were performed to assess diagnostic performance of various combinations of mpMRI parameters.<bold>Results: </bold>Of 137 patients, 32 were diagnosed with PCa on biopsy. Multivariable analysis, adjusted with positive pathology, showed apparent diffusion coefficient (ADC), metabolite ratio, and PSA as significant predictors of PCa (P < 0.05). A statistical equation was derived using these predictors. A simple 6-point mpMRI-based RS was derived for calculating the risk of PCa and it showed that it is highly predictive for PCa (odds ratio = 3.74, 95% confidence interval [CI]: 2.24-6.27, area under the curve [AUC] = 0.87). Both models (equation and RS) yielded high predictive performance (AUC ≥0.85) on validation analysis.<bold>Data Conclusion: </bold>A statistical equation and a simple 6-point mpMRI-based RS can be used as a point-of-care tool to potentially help limit the number of negative biopsies in men with PSA between 4 and 10 ng/mL.<bold>Level Of Evidence: </bold>1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1227-1236. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10531807
- Volume :
- 47
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Magnetic Resonance Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 129078538
- Full Text :
- https://doi.org/10.1002/jmri.25850