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Prostanoids and Hair Follicles: Implications for Therapy of Hair Disorders.
- Source :
- Acta Dermato-Venereologica; Mar2018, Vol. 98 Issue 3, p318-323, 6p
- Publication Year :
- 2018
-
Abstract
- Prostanoids, including prostaglandins (PGs) and thromboxane A<subscript>2</subscript> (TXA<subscript>2</subscript>), are a family of lipid-derived autacoids that modulate many physiological systems and pathological contexts. Prostanoids are generated by sequential metabolism of arachidonic acid, catalysed by cyclo-oxygenase, to PGH2, which is then converted to PGD<subscript>2</subscript>, PGE<subscript>2</subscript>, PGF<subscript>2α</subscript>, PGI<subscript>2</subscript> and TXA<subscript>2</subscript>, catalysed by their specific synthases. Recent evidence suggests that prostanoids play a role in regulating hair growth. The PGF<subscript>2α</subscript> analogue is Food and Drug Administrationapproved in the US and routinely used to enhance the growth of human eyelashes. PGE<subscript>2</subscript> is reported to protect from radiation-induced hair loss in mice. Conversely, PGD<subscript>2</subscript> inhibits hair growth. This paper reviews the metabolism of prostanoids and the expression pattern of prostanoid receptors in hair follicles, focussing on their different and opposing effects on hair growth and the underlying mechanisms. This has potential clinical relevance in the treatment and prevention of hair disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROSTANOIDS
HAIR diseases
HAIR growth
PHOSPHOLIPASES
PATIENTS
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 00015555
- Volume :
- 98
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Acta Dermato-Venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 129058288
- Full Text :
- https://doi.org/10.2340/00015555-2843