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Lung-Derived Exosomal miR-483-3p Regulates the Innate Immune Response to Influenza Virus Infection.
- Source :
- Journal of Infectious Diseases; 5/1/2018, Vol. 217 Issue 9, p1372-1382, 11p
- Publication Year :
- 2018
-
Abstract
- Exosomes regulate cell-cell communication by transferring functional proteins and RNAs between cells. Here, to clarify the function of exosomes during influenza virus infection, we characterized lung-derived exosomal microRNAs (miRNAs). Among the detected miRNAs, miR-483-3p was present at high levels in bronchoalveolar lavage fluid (BALF) exosomes during infection of mice with various strains of influenza virus, and miR-483-3p transfection potentiated gene expression of type I interferon and proinflammatory cytokine upon viral infection of MLE-12 cells. RNF5, a regulator of the RIG-I signaling pathway, was identified as a target gene of miR-483-3p. Moreover, we found that CD81, another miR-483-3p target, functions as a negative regulator of RIG-I signaling in MLE-12 cells. Taken together, this study indicates that BALF exosomal miRNAs may mediate the antiviral and inflammatory response to influenza virus infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- MICRORNA
INFLUENZA viruses
BRONCHOALVEOLAR lavage
CYTOKINES
INTERFERONS
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 217
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 129020428
- Full Text :
- https://doi.org/10.1093/infdis/jiy035