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Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans.
- Source :
- Emerging Infectious Diseases; Apr2018, Vol. 24 Issue 4, p746-750, 5p, 5 Color Photographs, 1 Black and White Photograph, 2 Charts, 2 Graphs
- Publication Year :
- 2018
-
Abstract
- To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence. [ABSTRACT FROM AUTHOR]
- Subjects :
- H7N9 Influenza
PATHOGENIC microorganisms
POLYMERASE chain reaction
VIRAL replication
MICROBIAL virulence
INFLUENZA epidemiology
AMINO acids
ANIMAL experimentation
COMPARATIVE studies
GENES
INFLUENZA
RESEARCH methodology
MEDICAL cooperation
MICE
GENETIC mutation
RESEARCH
RESEARCH funding
EVALUATION research
INFLUENZA A virus
ORTHOMYXOVIRUS infections
Subjects
Details
- Language :
- English
- ISSN :
- 10806040
- Volume :
- 24
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 128748711
- Full Text :
- https://doi.org/10.3201/eid2404.171509