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Suppressive effects of zingerone on TGFBIp-mediated septic responses.
- Source :
- Archives of Pharmacal Research; Mar2018, Vol. 41 Issue 3, p276-287, 12p
- Publication Year :
- 2018
-
Abstract
- Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to possess various pharmacological activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGF-β. TGFBIp is released by human umbilical vein endothelial cells and functions as a mediator of experimental sepsis. We hypothesized that ZGR could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of ZGR against TGFBIp-mediated septic responses. ZGR effectively inhibited lipopolysaccharide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury. In conclusion, ZGR suppressed TGFBIp-mediated and CLP-induced septic responses. Therefore, ZGR could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02536269
- Volume :
- 41
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Archives of Pharmacal Research
- Publication Type :
- Academic Journal
- Accession number :
- 128572947
- Full Text :
- https://doi.org/10.1007/s12272-017-0919-9