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Early prediction of cardiac resynchronization therapy response by non-invasive electrocardiogram markers.
- Source :
- Medical & Biological Engineering & Computing; Apr2018, Vol. 56 Issue 4, p611-621, 11p, 4 Charts, 5 Graphs
- Publication Year :
- 2018
-
Abstract
- Cardiac resynchronization therapy (CRT) is an effective treatment for those patients with severe heart failure. Regrettably, there are about one third of CRT "non-responders", i.e. patients who have undergone this form of device therapy but do not respond to it, which adversely affects the utility and cost-effectiveness of CRT. In this paper, we assess the ability of a novel surface ECG marker to predict CRT response. We performed a retrospective exploratory study of the ECG previous to CRT implantation in 43 consecutive patients with ischemic (17) or non-ischemic (26) cardiomyopathy. We extracted the QRST complexes (consisting of the QRS complex, the S-T segment, and the T wave) and obtained a measure of their energy by means of spectral analysis. This ECG marker showed statistically significant lower values for non-responder patients and, joint with the duration of QRS complexes (the current gold-standard to predict CRT response), the following performances: 86% accuracy, 88% sensitivity, and 80% specificity. In this manner, the proposed ECG marker may help clinicians to predict positive response to CRT in a non-invasive way, in order to minimize unsuccessful procedures. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01400118
- Volume :
- 56
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Medical & Biological Engineering & Computing
- Publication Type :
- Academic Journal
- Accession number :
- 128549167
- Full Text :
- https://doi.org/10.1007/s11517-017-1711-1