Palliative sedation in Germany: factors and treatment practices associated with different sedation rate estimates in palliative and hospice care services.

Background: Clinical practice of Palliative Sedation (PS) varies between institutions worldwide and sometimes includes problematic practices. Little available research points at different definitions and frameworks which may contribute to uncertainty of healthcare professionals in the application of PS. This analysis investigates what demographic factors and characteristics of treatment practices differ between institutions with high versus low sedation rates estimates in Palliative and Hospice Care in Germany. Methods: Data sets from 221 organisations from a prior online survey were separated into two sub-groups divided by their estimated sedation rate A) lower/equal to 16% (<italic>n</italic> = 187; 90.8%) and B) higher than 16% (<italic>n</italic> = 19; 9.2%) for secondary analysis. Demographic factors and characteristics of PS treatment practices between the two groups were compared using T-Tests and Chi²/ Fisher Exact Tests and considered significant (*) at two-sided <italic>p</italic> <.05. Results: Organisations in group B report that they discuss PS for a higher proportion of patients (38.5%/10.2%, <italic>p</italic> < 0.000**), rate agitation more often as an indications for PS (78.9%/ 53.5%, <italic>p</italic> = 0.050*), and are more likely to use Lorazepam (63.2%/ 37.4%, <italic>p</italic> = 0.047*), Promethazin (26.3%/ 9.6%, <italic>p</italic> = 0.044*), and (Es-)Ketamin (31.6%/ 12.8%, <italic>p</italic> = 0.039*) than representatives in group A. Both groups differ significantly in their allocation of three case scenarios to different types of PS. Conclusions: Both definitions and patterns of clinical practice between palliative and hospice care representatives show divergence, which may be influenced one by another. A comprehensive framework considering conceptual, clinical, ethical, and legal aspects of different definitions of PS could help to better distinguish between different types and nuances of PS. [ABSTRACT FROM AUTHOR]