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You have free access to this contentTargeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.

You have free access to this contentTargeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.

Authors :
Di Napoli, Arianna
Jain, Preti
Duranti, Enrico
Margolskee, Elizabeth
Arancio, Walter
Facchetti, Fabio
Alobeid, Bachir
Santanelli di Pompeo, Fabio
Mansukhani, Mahesh
Bhagat, Govind
Source :
British Journal of Haematology; Mar2018, Vol. 180 Issue 5, p741-744, 4p
Publication Year :
2018

Abstract

The article focuses on next generation sequencing of breast implant associated anaplastic large cell lymphoma (BI-ALCL) which reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A. It mentions BI-ALCL is characterized by the presence of CD30 with atypical lymphocytes frequently confined to the peri-implant seroma fluid. It also mentions identification of biomarkers that enable disease prognostication and optimal treatment.

Details

Language :
English
ISSN :
00071048
Volume :
180
Issue :
5
Database :
Complementary Index
Journal :
British Journal of Haematology
Publication Type :
Academic Journal
Accession number :
128179295
Full Text :
https://doi.org/10.1111/bjh.14431