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You have free access to this contentTargeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.
You have free access to this contentTargeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.
- Source :
- British Journal of Haematology; Mar2018, Vol. 180 Issue 5, p741-744, 4p
- Publication Year :
- 2018
-
Abstract
- The article focuses on next generation sequencing of breast implant associated anaplastic large cell lymphoma (BI-ALCL) which reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A. It mentions BI-ALCL is characterized by the presence of CD30 with atypical lymphocytes frequently confined to the peri-implant seroma fluid. It also mentions identification of biomarkers that enable disease prognostication and optimal treatment.
- Subjects :
- BREAST implants
ANAPLASTIC lymphoma kinase
LYMPHOCYTES
BIOMARKERS
GENETIC mutation
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 180
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 128179295
- Full Text :
- https://doi.org/10.1111/bjh.14431