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Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects.
- Source :
- Molecular Cancer; 9/21/2014, Vol. 13, p1-8, 8p, 2 Graphs
- Publication Year :
- 2014
-
Abstract
- Chimeric antigen receptors (CARs) are recombinant receptors that combine the specificity of an antigen-specific antibody with the T-cell's activating functions. Initial clinical trials of genetically engineered CAR T cells have significantly raised the profile of T cell therapy, and great efforts have been made to improve this approach. In this review, we provide a structural overview of the development of CAR technology and highlight areas that require further refinement. We also discuss critical issues related to CAR therapy, including the optimization of CAR T cells, the route of administration, CAR toxicity and the blocking of inhibitory molecules. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14764598
- Volume :
- 13
- Database :
- Complementary Index
- Journal :
- Molecular Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 128156921
- Full Text :
- https://doi.org/10.1186/1476-4598-13-219