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The Effect of Sanggua Drink Extract on Insulin Resistance through the PI3K/AKT Signaling Pathway.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 2/19/2018, Vol. 2018, p1-9, 9p, 1 Color Photograph, 9 Charts, 2 Graphs
- Publication Year :
- 2018
-
Abstract
- Treating type 2 diabetes mellitus (T2DM) using thiazolidinediones and biguanides can present several challenges for patients. Sanggua Drink (SGD) is a commonly used agent in traditional Chinese medicine, and it consists of<italic> Folium Mori</italic>,<italic> Fructus Momordicae Charantiae</italic>,<italic> Radix Puerariae Lobatae</italic>, and<italic> Rhizoma Dioscorea</italic>. The hypoglycemic effects and mechanisms of SGD extracts on insulin resistance in diabetic rats were investigated. SGD (1.24 g/kg orally) was verified in T2DM rats induced by a high-fat diet and streptozotocin. The results showed that SGD treatment was observed to reduce fasting blood glucose, water and food intake, total cholesterol triglycerides, and LDL, OGTT, FINS, HOMA-IR, GHb, and MDA and increase hepatic glycogen, HDL, SOD, CAT, and GSH-Px in diabetic rats. Simultaneously, SGD treatment by T2DM showed significantly ameliorated pathological changes and reduced inflammation in the pancreas. Treatment was also observed to increase gene and protein expressions of InsR, IRS-2, PI3K, AKT, and Glut4 in the livers of diabetic treated rats. These results suggest that SGD extracts have hypoglycemic properties and may alleviate insulin resistance in T2DM rats through the PI3K/AKT pathway. Therefore, SGD appears to be a promising insulin sensitizer. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of plant extracts
AMINOGLYCOSIDES
ANIMAL experimentation
BLOOD sugar
BUTYRIC acid
CELLULAR signal transduction
CHOLESTEROL
FASTING
FAT content of food
GENE expression
GLUCOSE tolerance tests
GLYCOGEN
HIGH density lipoproteins
HYPOGLYCEMIC agents
INFLAMMATION
INGESTION
INSULIN resistance
LOW density lipoproteins
CHINESE medicine
TYPE 2 diabetes
ORAL drug administration
PANCREAS
PHOSPHOTRANSFERASES
PROTEIN kinases
RATS
SODIUM
TRIGLYCERIDES
WATER
HYDROXY acids
GAMMA-hydroxybutyrate
MALONDIALDEHYDE
PLANT extracts
GLYCEMIC control
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2018
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 128079634
- Full Text :
- https://doi.org/10.1155/2018/9407945