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Sono-chemical synthesis and characterization of Fe3O4@mTiO2-GO nanocarriers for dual-targeted colon drug delivery.
- Source :
- Research on Chemical Intermediates; Mar2018, Vol. 44 Issue 3, p1889-1904, 16p, 1 Black and White Photograph, 1 Diagram, 1 Chart, 8 Graphs
- Publication Year :
- 2018
-
Abstract
- In this study, a kind of magnetic Fe<subscript>3</subscript>O<subscript>4</subscript>@mTiO<subscript>2</subscript>-GO (where m was shorted mesoporous) hybrids with core–shell nano-structure for controlled dual targeted drug delivery was synthesized using a facile sono-chemical method. The structure and chemical composition of the nanocarrier (NC), and its surface morphology, were studied by X-ray diffraction (XRD), scanning electron microscopy (SEM) with an energy dispersive X-ray (EDX), vibrating sample magnetometer (VSM) spectroscopy and Fourier transform infrared spectroscopy (FT-IR). Synthesis of Fe<subscript>3</subscript>O<subscript>4</subscript>@mTiO<subscript>2</subscript>-GO was proved by XRD and FT-IR. SEM showed that the particle size of this NC was in the range of ∼ 85–95 nm. EDX confirmed the presence of Ti, Fe, C and O in the nanocarrier. VSM analysis showed the magnetic behavior of the Fe<subscript>3</subscript>O<subscript>4</subscript>@mTiO<subscript>2</subscript>-GO nano-hybrids with saturation magnetization (<italic>M</italic><subscript>S</subscript>) of 1.57 emu/g at room temperature. Curcumin (CUR) as a hydrophobic and an anti-tumor model drug was loaded on the NC. Drug loading capacity and encapsulation efficiency of this NC were as high as 17.85 and 72.45%, respectively. The drug release behavior was sustained and pH-responsive. MTT results demonstrated no significant cytotoxicity of the NC on Human Foreskin Fibroblast Normal cell line (HFF-2), indicating that this NC can be safe for use as a drug carrier for delivering anticancer drugs to tumor sites. The results of an MTT test on Caco-2 cancerous cells proved that CUR in nano-carriers has retained its anti-cancer properties. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09226168
- Volume :
- 44
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Research on Chemical Intermediates
- Publication Type :
- Academic Journal
- Accession number :
- 128053396
- Full Text :
- https://doi.org/10.1007/s11164-017-3204-0