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Survival Outcome of Intermediate-Grade Salivary Gland Carcinoma.
- Source :
- Oncology; Feb2018, Vol. 94 Issue 2, p125-132, 8p, 3 Charts, 1 Graph
- Publication Year :
- 2018
-
Abstract
- Objective: Histological grade is the most important factor for defining treatment strategies and predicting prognosis for salivary gland carcinoma (SGC). We examined factors affecting long-term recurrence and survival among intermediate-grade SGC (IGSGC) patients to define optimal treatment modalities and outcomes. Methods: We reviewed the clinical and pathological data on 108 IGSGC patients who underwent definitive surgery with or without postoperative radiotherapy. We compared treatment outcomes by treatment strategies such as surgical extent for the primary tumor, neck dissection, or postoperative radiotherapy. Results: During a 103-month median follow-up, local, regional, and distant recurrences were detected in 14 (13.0%), 3 (2.8%), and 21 (19.4%) patients, respectively. The 10-year locoregional control (LRC), distant metastasis-free survival (DMFS), and overall survival (OS) rates were 83.1, 76.0, and 80.1%, respectively. Multivariate analyses identified a nonparotid primary site as an independent prognostic factor for LRC (p = 0.018). Adenoid cystic carcinoma and a positive pN classification were significantly unfavorable prognostic factors for DMFS (p = 0.025 and p = 0.030, respectively); overall advanced stage was an independent prognostic factor for OS (p = 0.020). Surgical extent, elective neck dissection, and postoperative adjuvant radiotherapy did not significantly affect treatment outcomes. Conclusion: Patients with early-stage IGSGC of parotid origin can achieve favorable treatment outcomes with conservative surgery alone. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANCER relapse
ADENOID cystic carcinoma
CANCER
COMBINED modality therapy
PATIENT aftercare
METASTASIS
MULTIVARIATE analysis
NECK surgery
PAROTID gland tumors
POSTOPERATIVE period
SURVIVAL
SALIVARY gland tumors
TUMOR classification
TREATMENT effectiveness
PROGNOSIS
TUMOR treatment
CANCER risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 00302414
- Volume :
- 94
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 127727304
- Full Text :
- https://doi.org/10.1159/000484411