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The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel.
- Source :
- PLoS Pathogens; 1/31/2018, Vol. 14 Issue 1, p1-21, 21p
- Publication Year :
- 2018
-
Abstract
- Potassium (K<superscript>+</superscript>) is required by plants for growth and development, and also contributes to immunity against pathogens. However, it has not been established whether pathogens modulate host K<superscript>+</superscript> signaling pathways to enhance virulence and subvert host immunity. Here, we show that the effector protein AvrPiz-t from the rice blast pathogen Magnaporthe oryzae targets a K<superscript>+</superscript> channel to subvert plant immunity. AvrPiz-t interacts with the rice plasma-membrane-localized K<superscript>+</superscript> channel protein OsAKT1 and specifically suppresses the OsAKT1-mediated K<superscript>+</superscript> currents. Genetic and phenotypic analyses show that loss of OsAKT1 leads to decreased K<superscript>+</superscript> content and reduced resistance against M. oryzae. Strikingly, AvrPiz-t interferes with the association of OsAKT1 with its upstream regulator, the cytoplasmic kinase OsCIPK23, which also plays a positive role in K<superscript>+</superscript> absorption and resistance to M. oryzae. Furthermore, we show a direct correlation between blast disease resistance and external K<superscript>+</superscript> status in rice plants. Together, our data present a novel mechanism by which a pathogen suppresses plant host immunity by modulating a host K<superscript>+</superscript> channel. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15537366
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- PLoS Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 127679750
- Full Text :
- https://doi.org/10.1371/journal.ppat.1006878