Synthesis of a pseudotetrasaccharide corresponding to a repeating unit of the Streptococcus pneumoniae type 6B capsular polysaccharide.

2-Aminoethyl glycoside of the pseudotetrasaccharide α-d-Glcp-(1→3)-α-l-Rhap-(1→4)-d-Rib-ol-(5-P-2)-α-d-Galpstructurally related to a repeating unit of theStreptococcus pneumoniaetype 6B capsular polysaccharide has been synthesized. At the key step, suitably protected pseudotrisaccharide α-d-Glcp-(1→3)-α-l-Rhap-(1→4)-d-Rib-ol with a free 5-OH group in the ribitol moiety and 2-OH α-galactoside were connected via a phosphate bridge using the hydrogen phosphonate procedure. [ABSTRACT FROM PUBLISHER]