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Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study.
- Source :
- British Journal of Sports Medicine; Feb2018, Vol. 52 Issue 3, p192-198, 7p, 1 Diagram, 4 Charts
- Publication Year :
- 2018
-
Abstract
- <bold>Background/aim: </bold>To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes.<bold>Methods: </bold>A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion.<bold>Results: </bold>The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders.<bold>Conclusions: </bold>IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03063674
- Volume :
- 52
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- British Journal of Sports Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 127611442
- Full Text :
- https://doi.org/10.1136/bjsports-2016-097419