Structural whole‐brain covariance of the anterior and posterior hippocampus: Associations with age and memory.

Abstract: The hippocampus (HC) interacts with distributed brain regions to support memory and shows significant volume reductions in aging, but little is known about age effects on hippocampal whole‐brain structural covariance. It is also unclear whether the anterior and posterior HC show similar or distinct patterns of whole‐brain covariance and to what extent these are related to memory functions organized along the hippocampal longitudinal axis. Using the multivariate approach partial least squares, we assessed structural whole‐brain covariance of the HC in addition to regional volume, in young, middle‐aged and older adults (<italic>n</italic> = 221), and assessed associations with episodic and spatial memory. Based on findings of sex differences in both memory and brain aging, we further considered sex as a potential modulating factor of age effects. There were two main covariance patterns: one capturing common anterior and posterior covariance, and one differentiating the two regions by capturing anterior‐specific covariance only. These patterns were differentially related to associative memory while unrelated to measures of single‐item memory and spatial memory. Although patterns were qualitatively comparable across age groups, participants' expression of both patterns decreased with age, independently of sex. The results suggest that the organization of hippocampal structural whole‐brain covariance remains stable across age, but that the integrity of these networks decreases as the brain undergoes age‐related alterations. [ABSTRACT FROM AUTHOR]