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Ruthenium(II)‐Catalyzed C−H Difluoromethylation of Ketoximes: Tuning the Regioselectivity from the <italic>meta</italic> to the <italic>para</italic> Position.
- Source :
- Angewandte Chemie International Edition; 1/26/2018, Vol. 57 Issue 5, p1277-1281, 5p
- Publication Year :
- 2018
-
Abstract
- Abstract: A highly <italic>para</italic>‐selective C<subscript>Ar</subscript>−H difluoromethylation of ketoxime ethers under ruthenium catalysis has been developed. A wide variety of ketoxime ethers are compatible with the reaction, which leads to the corresponding <italic>para</italic>‐difluoromethylated products in moderate to good yield. A mechanistic study clearly showed that chelation‐assisted cycloruthenation is the key factor in the <italic>para</italic> selectivity of the difluoromethylation of ketoxime ethers. Density functional theory was used to gain a theoretical understanding of the <italic>para</italic> selectivity.# [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 57
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 127501323
- Full Text :
- https://doi.org/10.1002/anie.201711221