DNA methylation alterations in the genome of a toddler with cri‐du‐chat syndrome.

Authors :: Naumova, Oxana Y.
Rychkov, Sergey Y.
Kuznetzova, Tatyana V.
Odintsova, Veronika V.
Kornilov, Sergey A.
Grigorenko, Elena L.
Source :: Clinical Case Reports; Jan2018, Vol. 6 Issue 1, p14-17, 4p
Publication Year :: 2018
Abstract: Key Clinical Message: This manuscript reports on genomewide epigenetic alterations in cri‐du‐chat syndrome related to a partial aneusomy of chromosome 5. A systematic analysis of these alterations will open up new possibilities for the prognostic evaluation of CDCS patients and the development of new therapeutic interventions for reducing the severity of the disease. [ABSTRACT FROM AUTHOR]

Subjects :: DNA methylation
CHROMOSOME abnormalities
MEDICAL genetics
PROGNOSTIC tests
GENETIC mutation

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