Back to Search
Start Over
Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-regression analysis.
- Source :
- Age & Ageing; Jan2018, Vol. 47 Issue 1, p9-17, 9p, 2 Charts, 1 Graph
- Publication Year :
- 2018
-
Abstract
- Background and objective: the study analysed the effectiveness and safety of warfarin use compared with warfarin nonuse and non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients aged ≥65 years. Methods: after searching PubMed and the Cochrane Library, 26 studies were included, with 10 comparing warfarin with warfarin non-use and 16 comparing warfarin with NOACs, in older AF patients (≥65 years). Results: warfarin use was superior to no antithrombotic therapy [relative risk (RR) 0.59, 95% confidence interval (CI) 0.51--0.76, I² = 12.3%, n = 8] and aspirin (RR 0.44, 95% CI 0.24-0.64, I² = 0.0%, n = 5) for stroke/thromboembolism (TE) prevention. Warfarin use was associated with a non-significant increase in risk of major bleeding compared with no antithrombotic therapy (RR 1.26, 95% CI 0.99--1.52, I² = 0.0%, n = 7) and aspirin (RR 1.20, 95% CI 0.91-1.50, I² = 0.0%, n = 5). NOACs were superior to warfarin for stroke/TE prevention [hazard ratio (HR) 0.81, 95% CI 0.73-0.89, I² = 56.6%, n = 9], and also were associated with reduced risk of major bleeding compared to warfarin (HR 0.87, 0.77-0.97, I² = 86.1%, n = 9). Conclusions: warfarin use was superior to warfarin non-use, aspirin and no antithrombotic therapy in reducing the risk of stroke/TE in older AF patients, but with a possible increase in major bleeding. NOACs were superior to warfarin for stroke/TE prevention, with reduced risk of major bleeding. [ABSTRACT FROM AUTHOR]
- Subjects :
- THROMBOEMBOLISM prevention
STROKE prevention
TREATMENT effectiveness
ANTICOAGULANTS
ASPIRIN
ATRIAL fibrillation
CONFIDENCE intervals
HEMORRHAGE
INFORMATION storage & retrieval systems
MEDICAL databases
MEDLINE
META-analysis
ONLINE information services
ORAL drug administration
PHARMACOLOGY
SYSTEMATIC reviews
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 00020729
- Volume :
- 47
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Age & Ageing
- Publication Type :
- Academic Journal
- Accession number :
- 127189146
- Full Text :
- https://doi.org/10.1093/ageing/afx103