New asymmetrical bispyrrolidinoindoline diketopiperazines from the marine fungus Aspergillus sp. DX4H.

Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1–3) had been isolated from the culture broth of a marine gut fungusAspergillussp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey’s method. Their inhibitory activity against PC3 cell line had been tested. [ABSTRACT FROM PUBLISHER]