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MiR-107 suppresses cell proliferation and tube formation of Ewing sarcoma cells partly by targeting HIF-1β.
- Source :
- Human Cell; Jan2018, Vol. 31 Issue 1, p42-49, 8p
- Publication Year :
- 2018
-
Abstract
- MicroRNAs serve a crucial role in the regulation of malignant biological behavior of Ewing's sarcoma (ES). Abnormal expression of miR-107 has been reported in a cohort of cancers, while its exact function in ES remains unclear. Hence, we explored the expression of miR-107 in ES cells and detected its effects on the malignant phenotype of ES cells. Firstly, we perceived the under-expression of miR-107 in human ES cells contrast with the human mesenchymal stem cells. Over-expression of miR-107 restrained cell proliferation and tube formation, arrested cell cycle progression, and facilitated cell apoptosis in SK-ES-1 and RD-ES cell lines. Furthermore, hypoxia inducible factor-1β (HIF-1β) was assumed as a target gene of miR-107. We confirmed the target role of HIF-1β in ES cells. Finally, restoring the expression of HIF-1β could partly abolish miR-107-mediated tumor suppression in ES cells. In conclusion, our results advised that miR-107 suppressed the malignant biological ability of ES cells through targeting HIF-1β. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09147470
- Volume :
- 31
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Human Cell
- Publication Type :
- Academic Journal
- Accession number :
- 126984907
- Full Text :
- https://doi.org/10.1007/s13577-017-0183-9