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Combined effects of leaks, respiratory system properties and upper airway patency on the performance of home ventilators: a bench study.
- Source :
- BMC Pulmonary Medicine; 11/21/2017, Vol. 17, p1-9, 9p, 2 Diagrams, 1 Chart, 3 Graphs
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Combined effects of leaks, mechanical property of respiratory system and upper airway (UA) patency on patient-ventilator synchrony (PVA) and the level of clinically "tolerable" leaks are not well established in home ventilators.<bold>Methods: </bold>We comparatively assessed on a bench model, the highest leak level tolerated without inducing significant asynchrony ("critical leak") in three home ventilators (Astral 150, Trilogy 100 and Vivo 60; noted as A150, T100 and V60 respectively) subjected to three simulated diseased respiratory conditions: chronic obstructive pulmonary disease (COPD), obesity hypoventilation (OHS) and neuromuscular disorders (NMD), with both open and closed UA. Also, total leak values in the device reports were compared to the bench-measured values.<bold>Results: </bold>With open UA, all ventilators were able to avoid asynchrony up to a 30 L/min leak and even to 55 L/min in some cases. UA closure and respiratory diseases especially OHS influenced PVA. With closed UA, the critical leak of A150 and T100 remained higher than 55 L/min in COPD and OHS, while for V60 decreased to 41 and 33 L/min respectively. In NMD with closed UA, only T100 reached a high critical leak of 69 L/min. Besides, inspiratory trigger sensitivity change was often necessary to avoid PVA.<bold>Conclusions: </bold>Home ventilators were able to avoid PVA in high-level leak conditions. However, asynchrony appeared in cases of abnormal mechanical properties of respiratory system or closed UA. In case of closed UA, the EPAP should be adjusted prior to the inspiratory trigger.<bold>Trial Registration: </bold>Not applicable. [ABSTRACT FROM AUTHOR]
- Subjects :
- MECHANICAL ventilators
RESPIRATORY diseases
OBSTRUCTIVE lung diseases
HYPOVENTILATION
RESPIRATION
OBSTRUCTIVE lung disease treatment
NEUROMUSCULAR diseases
HEALTH self-care
ARTIFICIAL respiration equipment
PICKWICKIAN syndrome
BIOLOGICAL models
CLINICAL trials
COMPARATIVE studies
RESEARCH methodology
MEDICAL cooperation
RESEARCH
TRACHEA
PRODUCT design
EVALUATION research
MEDICAL equipment reliability
RESPIRATORY mechanics
THERAPEUTICS
EQUIPMENT & supplies
Subjects
Details
- Language :
- English
- ISSN :
- 14712466
- Volume :
- 17
- Database :
- Complementary Index
- Journal :
- BMC Pulmonary Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 126974480
- Full Text :
- https://doi.org/10.1186/s12890-017-0487-2