Front Cover: Intra- versus Intermolecular Hydrogen Bonding: Solvent-Dependent Conformational Preferences of a Common Supramolecular Binding Motif from 1H NMR and Vibrational Circular Dichroism Spectra (Chem. Eur. J. 71/2017).

This work shows that the intuitive assumption of the sterically less hindered amide group being solvated preferentially does not hold for the cases of two 2,6‐pyridinediyl‐dialkylamides. Using vibrational circular dichroism (VCD) spectroscopy, solvation is found to induce significant conformational changes, which are not immediately apparent from 1H NMR data. More information can be found in the Full Paper by D. P. Demarque and C. Merten on page 17915. [ABSTRACT FROM AUTHOR]