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Predicting the pathogenicity of novel variants in mitochondrial tRNA with MitoTIP.
- Source :
- PLoS Computational Biology; 12/11/2017, Vol. 13 Issue 12, p1-8, 8p
- Publication Year :
- 2017
-
Abstract
- Novel or rare variants in mitochondrial tRNA sequences may be observed after mitochondrial DNA analysis. Determining whether these variants are pathogenic is critical, but confirmation of the effect of a variant on mitochondrial function can be challenging. We have used available databases of benign and pathogenic variants, alignment between diverse tRNAs, structural information and comparative genomics to predict the impact of all possible single-base variants and deletions. The Mitochondrial tRNA Informatics Predictor (MitoTIP) is available through MITOMAP at . The source code for MitoTIP is available at . [ABSTRACT FROM AUTHOR]
- Subjects :
- MITOCHONDRIAL DNA
DNA analysis
PATHOGENIC microorganisms
GENOMICS
MOLECULAR biology
Subjects
Details
- Language :
- English
- ISSN :
- 1553734X
- Volume :
- 13
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- PLoS Computational Biology
- Publication Type :
- Academic Journal
- Accession number :
- 126688349
- Full Text :
- https://doi.org/10.1371/journal.pcbi.1005867