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Patterns of late-life depressive symptoms and subsequent declines in cognitive domains.
- Source :
- International Journal of Geriatric Psychiatry; Dec2017, Vol. 32 Issue 12, p1330-1341, 12p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Depression frequently co-occurs with cognitive decline, but the nature of this association is unclear. We examined relations of late-life depressive symptom patterns to subsequent domain-specific cognitive changes.<bold>Methods: </bold>Depressive symptoms were measured at up to 3 timepoints among 11,675 Nurses' Health Study participants prior to cognitive testing. Depressive symptom patterns were categorized as non-depressed, variable or persistent, based on published severity cutpoints. Outcomes were global, verbal, and executive function-attention composite scores.<bold>Results: </bold>Participants with persistent depressive symptoms had worse executive function-attention decline compared with non-depressed participants (multivariable-adjusted mean difference = -0.03 units/year, 95% CI: -0.05, -0.01; p = 0.003); this difference was comparable with 8 years of aging. However, being in the persistent versus non-depressed group was not significantly related to verbal (p = 0.71) or global score (p = 0.09) decline. By contrast, compared with the non-depressed group, those with variable depressive symptoms had worse verbal memory decline (multivariable-adjusted mean difference = -0.01 units/year, 95% CI: -0.02, -0.002; p = 0.03); this group showed no differences for global or executive function-attention decline.<bold>Conclusions: </bold>A variable pattern of depressive symptom severity related to subsequent decline in verbal memory, while a persistent pattern related to decline in executive function-attention. Findings could signal differences in underlying neuropathologic processes among persons with differing depression patterns and late-life cognitive decline. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08856230
- Volume :
- 32
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- International Journal of Geriatric Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 126462081
- Full Text :
- https://doi.org/10.1002/gps.4618