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A randomized phase II trial of geriatric assessment and management for older cancer patients.
- Source :
- Supportive Care in Cancer; Jan2018, Vol. 26 Issue 1, p109-117, 9p
- Publication Year :
- 2018
-
Abstract
- <bold>Purpose: </bold>Geriatric assessment and management (GAM) can identify current health issues and recommend interventions to optimize well-being of older adults, but no randomized trial has yet been completed in oncology. Therefore, a randomized phase 2 trial was conducted.<bold>Methods: </bold>A two-group parallel single-blinded randomized phase II trial ( ClinicalTrials.gov Identifier: NCT02222259) enrolled patients aged ≥70 years, diagnosed with stage 2-4 gastrointestinal, genitourinary, or breast cancer within 6 weeks of commencing chemotherapy at Princess Margaret Cancer Centre. The coprimary feasibility outcomes were the proportion of eligible patients enrolled and retained. The coprimary clinical outcomes were quality of life (QOL) (EORTC QLQ C30) and modification of cancer treatment. Descriptive and regression analyses using intent-to-treat analysis were conducted.<bold>Results: </bold>Sixty-one persons (64%) agreed to participate (31 allocated to intervention arm and 30 to control group). In the control group, more participants died and refused follow-up. The benefit of intervention over control on QOL at 3 months was greater for those who survived 6 months (difference 9.28; 95% CI -10.35 to 28.91) versus those who survived only 3 months (difference 6.55; 95% CI -9.63 to 22.73).<bold>Conclusions: </bold>This trial showed that it was feasible to recruit and retain older adults for a GAM study. Those who survived at least 6 months seemed to receive a greater QOL benefit than those who died or withdrew. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANCER patient care
CANCER patient medical care
MEDICAL care for older people
CANCER patients
QUALITY of life
GERIATRIC assessment
MENTAL health
TUMOR treatment
COMPARATIVE studies
RESEARCH methodology
MEDICAL cooperation
QUESTIONNAIRES
RESEARCH
RESEARCH funding
TUMORS
EVALUATION research
RANDOMIZED controlled trials
Subjects
Details
- Language :
- English
- ISSN :
- 09414355
- Volume :
- 26
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Supportive Care in Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 126418044
- Full Text :
- https://doi.org/10.1007/s00520-017-3820-7