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Claudin-1 expression in cervical cancer.
- Source :
- Molecular & Clinical Oncology; 2017, Vol. 7 Issue 5, p880-884, 5p
- Publication Year :
- 2017
-
Abstract
- Claudin-1 is a tight junction protein that has been demonstrated to be involved in tumorigenesis and tumor progression in various types of solid tumors. In the present study, the protein expression of claudin-1 in squamous cervical cancer tissues obtained from 106 patients was analyzed by immunohistochemistry. In addition, the grade of claudin-1 expression was analyzed for associations with certain clinicopathological parameters. A significant overexpression of claudin-1 was detected in the tumor cells, when compared with that in the peritumoral stroma. There was no significant association between claudin-1 expression and FIGO stage, tumor size, grading or the appearance of distant metastases. Cervical cancer patients scoring positive for claudin-1 protein expression tended to exhibit more lymph node metastasis (28.3%), compared with claudin-1-negative patients (7.1%). Regarding overall survival, the results of the present study suggest a better prognosis for claudin-1-negative patients. In order to elucidate whether claudin-1 overexpression has a significant prognostic impact on squamous cervical cancer, further studies are required. [ABSTRACT FROM AUTHOR]
- Subjects :
- CLAUDINS
CERVICAL cancer
Subjects
Details
- Language :
- English
- ISSN :
- 20499450
- Volume :
- 7
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Molecular & Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 126409694
- Full Text :
- https://doi.org/10.3892/mco.2017.1391