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Predictors of early-onset post-ischemic stroke depression: a cross-sectional study.

Authors :
Guilin Meng
Xiaoye Ma
Lei Li
Yan Tan
Xiaohui Liu
Xueyuan Liu
Yanxin Zhao
Meng, Guilin
Ma, Xiaoye
Li, Lei
Tan, Yan
Liu, Xiaohui
Liu, Xueyuan
Zhao, Yanxin
Source :
BMC Neurology; 11/17/2017, Vol. 17, p1-8, 8p, 1 Diagram, 4 Charts
Publication Year :
2017

Abstract

<bold>Background: </bold>Post-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality of life. However, the pathogenesis of PSD is still not clear. This study aimed to investigate the demographic, clinical, and biochemical factors in patients with PSD.<bold>Methods: </bold>Patients with an acute ischemic stroke, who met the inclusion criteria at Shanghai Tenth People's Hospital from April 2016 to September 2016, were recruited for this study. The stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), and the mental state was assessed using Mini-Mental State Examination (MMSE), Hamilton Depression Scale (HAMD), and Hamilton Anxiety Scale (HAMA) at 1 week of admission. The patients were divided into PSD and non-PSD groups. The demographic and clinical characteristics, as well as the biochemical factors, were compared between the two groups. A logistic regression analysis was performed to identify the risk factors for depression following stroke.<bold>Results: </bold>A total of 83 patients with acute ischemic stroke were recruited. Of these, 36 (43.4%) developed depression. The multivariate logistic regression analysis indicated that high NIHSS [odds ratio (OR): 1.84, 95% confidence interval (CI): 1.09-3.12, P = 0.023] and high HAMD scores (OR: 2.38, 95% CI: 1.61-3.50, P < 0.001) were independent risk predictors for PSD and so were lower dopamine level (OR: 0.64, 95% CI: 0.45-0.91, P = 0.014), lower 5-hydroxytryptamine level (OR: 0.99, 95% CI: 0.98-1.00, P = 0.046), higher tumor necrosis factor-α level (OR: 1.05, 95% CI: 1.00-1.09, P = 0.044), and lower nerve growth factor level (OR: 0.06, 95% CI: 0.01-0.67, P = 0.022).<bold>Conclusions: </bold>The identification of higher NIHSS scores, higher HAMD scores, lower dopamine level, lower 5-hydroxytryptamine level, higher tumor necrosis factor-α level, and lower nerve growth factor level might be useful for clinicians in recognizing and treating depression in patients after a stroke. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712377
Volume :
17
Database :
Complementary Index
Journal :
BMC Neurology
Publication Type :
Academic Journal
Accession number :
126310448
Full Text :
https://doi.org/10.1186/s12883-017-0980-5