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Dopaminergic stimulation in unilateral neglect.
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry; Sep1998, p344-347, 4p
- Publication Year :
- 1998
-
Abstract
- <bold>Objective: </bold>To explore the hypothesis that dopaminergic circuits play a part in the premotor components of the unilateral neglect syndrome, the effects of acute dopaminergic stimulation in patients with neglect were studied.<bold>Methods: </bold>Two tasks were evaluated before and after subcutaneous administration of apomorphine and placebo: a circle crossing test and a test of target exploration (a modified version of the bell test), performed both in perceptual (counting) and in perceptual-motor (pointing) conditions.<bold>Subjects: </bold>Four patients with left neglect.<bold>Results: </bold>After dopaminergic stimulation, a significant improvement was found compared with placebo administration and baseline evaluation, in the performance of the two tests. Three of the patients had a more marked improvement in the perceptual-motor condition (pointing) of the task than the perceptual condition (counting).<bold>Conclusions: </bold>The findings suggest that dopaminergic neuronal networks may mediate, in different ways, both perceptive and premotor components of the unilateral neglect syndrome. [ABSTRACT FROM AUTHOR]
- Subjects :
- APOMORPHINE
ATTENTION
CEREBRAL dominance
CLINICAL trials
COMPARATIVE studies
DOPAMINE
DOPAMINE agonists
HEMIPLEGIA
INFARCTION
RESEARCH methodology
MEDICAL cooperation
PSYCHOLOGY of movement
NERVOUS system
MENTAL orientation
RESEARCH
EVALUATION research
RANDOMIZED controlled trials
ACUTE diseases
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00223050
- Database :
- Complementary Index
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 126271920