Back to Search Start Over

The preoperative neutrophil to lymphocyte ratio is a superior indicator of prognosis compared with other inflammatory biomarkers in resectable colorectal cancer.

Authors :
Yongxi Song
Yuchong Yang
Peng Gao
Xiaowan Chen
Dehao Yu
Yingying Xu
Junhua Zhao
Zhenning Wang
Song, Yongxi
Yang, Yuchong
Gao, Peng
Chen, Xiaowan
Yu, Dehao
Xu, Yingying
Zhao, Junhua
Wang, Zhenning
Source :
BMC Cancer; 11/10/2017, Vol. 17, p1-8, 8p, 3 Charts, 2 Graphs
Publication Year :
2017

Abstract

<bold>Background: </bold>Growing evidence has indicated that some inflammatory markers, including lymphocyte to monocyte ratio (LMR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI), can be used as indicators in the prognosis of colorectal cancer (CRC). However, there is controversy concerning what is the best predictor of prognosis in CRC.<bold>Methods: </bold>A cohort of 1744 CRC patients in our institution was analyzed retrospectively. Harrell's concordance index (c-index) and Bayesian information criterion (BIC) were used to determine the optimal cut-off values of inflammatory markers and compare their predictive capacity. The association of inflammatory markers with overall survival (OS) and cancer-specific survival (CSS) was analyzed using Kaplan-Meier methods with log-rank test, followed by multivariate Cox proportional hazards model.<bold>Results: </bold>The multivariate analysis indicated that among these inflammatory markers, NLR (< 2.0 vs. ≥ 2.0) was the only independent prognostic factor for poor OS [hazard ratio (HR) = 0.758, 95% confidence intervals (CI) = 0.598-0.960, P = 0.021)] and CSS (HR = 0.738, 95% CI = 0.573-0.950, P = 0.018). Among these inflammatory markers, the c-index and BIC value for NLR were maximum and minimum for OS, respectively. In addition, the c-index was higher and the BIC value was smaller in TNM staging combined with NLR compared with the values obtained in TNM staging alone.<bold>Conclusion: </bold>NLR is a superior indicator of prognosis compared with LMR, PLR, and PNI in CRC patients, and NLR may serve as an additional indicator based on the current tumor staging system. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712407
Volume :
17
Database :
Complementary Index
Journal :
BMC Cancer
Publication Type :
Academic Journal
Accession number :
126184523
Full Text :
https://doi.org/10.1186/s12885-017-3752-0