Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers.

Authors :: Nilsson, Monique B.
Huiying Sun
Lixia Diao
Pan Tong
Diane Liu
Lerong Li
Youhong Fan
Poteete, Alissa
Seung-Oe Lim
Howells, Kathryn
Haddad, Vincent
Gomez, Daniel
Hai Tran
Armaiz Pena, Guillermo
Sequist, Lecia V.
Yang, James C.
Jing Wang
Kim, Edward S.
Herbst, Roy
Lee, J. Jack
Source :: Science Translational Medicine; 11/8/2017, Vol. 9 Issue 415, p1-10, 10p
Publication Year :: 2017
Abstract: The article presents the study on the role of stress hormones in activating epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in non-small cell lung cancer (NSCLC) cell. Topics include the association between beta<subscript>2</subscript>-adrenergic receptors (beta<subscript>2</subscript>-ARs) and tumor growth, the role of interleukin-6 (IL-6) on EGFR TKI outcome, and the result which provide evidences on the role of chronic stress hormones in promoting EGFR TKI resistance.

Subjects :: EPIDERMAL growth factor receptors
PROTEIN-tyrosine kinase inhibitors
CANCER treatment
NON-small-cell lung carcinoma
BETA adrenoceptors
ADRENERGIC beta blockers
INTERLEUKIN-6

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