Back to Search
Start Over
Effect of renal denervation on urine angiotensinogen excretion in prenatally programmed rats.
- Source :
- Physiological Reports; Nov2017, Vol. 5 Issue 20, pn/a-N.PAG, 8p
- Publication Year :
- 2017
-
Abstract
- Prenatal programming results in an increase in blood pressure in adult offspring. We have shown that compared to control adult offspring whose mothers were fed a 20% protein diet, programmed adults whose mothers were fed a 6% protein diet during the last half of pregnancy have an increase in renal sympathetic nerve activity and urinary angiotensinogen/creatinine levels. We hypothesized that the increase in urinary angiotensinogen was mediated by renal sympathetic nerve activity in programmed rats. In this study performed in 3 month old rats, renal denervation resulted in normalization of blood pressure in the 6% programmed group (150 ± 3 Hg in 6% sham vs. 121 ± 4 Hg in 6% denervated, P < 0.001), and a reduction in blood pressure in the 20% group (126 ± 2 Hg 20% sham vs. 113 ± 4 Hg 20% denervated ( P < 0.05). We confirm that the intrarenal renin-angiotensin system assessed by urinary angiotensinogen/creatinine is upregulated in offspring of rats fed a 6% protein diet rats compared to 20% controls. To determine if sympathetic nerve activity was mediating the increase in urinary angiotensinogen in programmed rats, we compared denervated to sham-operated control and programmed rats. Renal denervation had no effect on urinary angiotensinogen/creatinine ratio in the 20% group and no effect on the increased urinary angiotensinogen/creatinine ratio found in programmed rats. This study demonstrates that the increase in urinary angiotensinogen in programmed rats is not mediated by renal sympathetic nerve activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- DENERVATION
BLOOD pressure
ANGIOTENSINOGEN
CREATININE
FETAL monitoring
Subjects
Details
- Language :
- English
- ISSN :
- 2051817X
- Volume :
- 5
- Issue :
- 20
- Database :
- Complementary Index
- Journal :
- Physiological Reports
- Publication Type :
- Academic Journal
- Accession number :
- 125996003
- Full Text :
- https://doi.org/10.14814/phy2.13482