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Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
- Source :
- Science Translational Medicine; 11/1/2017, Vol. 9 Issue 414, p1-11, 11p
- Publication Year :
- 2017
-
Abstract
- The article presents a study which identified certain vulnerabilities in cancers that express PGBD5, a DNA transposase. The study found that expression of PGBD5 is not tolerated by cells in mice and human beings which lack nonhomologous end joining DNA repair. Examination of cell survival and DNA damage was done using Western immunoblotting.
- Subjects :
- CANCER
TRANSPOSASES
DNA repair
CELLS
TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 19466234
- Volume :
- 9
- Issue :
- 414
- Database :
- Complementary Index
- Journal :
- Science Translational Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 125979443
- Full Text :
- https://doi.org/10.1126/scitranslmed.aam9078