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The Impact of Diet-Induced Weight Loss on Biomarkers for Colorectal Cancer: An Exploratory Study (INTERCEPT).
- Source :
- Obesity (19307381); Nov2017 Supplement S2, Vol. 25, pS95-S101, 7p
- Publication Year :
- 2017
-
Abstract
- <bold>Objective: </bold>The aim of this study was to explore the potential effects of diet-induced weight loss on molecular biomarkers of colorectal cancer risk in serum and colorectal tissue.<bold>Methods: </bold>This single-arm exploratory study included 20 adults with BMI ≥ 30 kg/m2 completing an 8-week, complete, low-energy liquid diet. Pre- and postintervention anthropometric measurements, fasting blood draws, and endoscopic examinations to procure colorectal biopsies were performed. Fasting insulin, glucose, insulinlike growth factor 1 (IGF-1), C-reactive protein (CRP), and blood lipids were measured in serum, and tissue markers of apoptosis (M30), colonocyte proliferation (Ki-67), and insulin signaling (phospho-mTOR) were assessed using immunohistochemical staining.<bold>Results: </bold>Participants achieved substantial weight loss (mean = 13.56%). Mean concentrations of insulin, glucose, and cholesterol were significantly reduced (P < 0.05), but IGF-1 and CRP were not. Colorectal tissue expression of Ki-67 was significantly reduced (preintervention mean score = 7, postintervention mean score = 3.9, mean % change -43.8; P = 0.027). There were no significant changes in M30 or phospho-mTOR.<bold>Conclusions: </bold>Weight loss in individuals with obesity was associated with improvements in insulin sensitivity and blood lipid profiles and a significant reduction in tissue Ki-67 expression. This is one of the first studies to demonstrate potential cancer-relevant changes in colorectal tissue following weight loss achieved through diet. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19307381
- Volume :
- 25
- Database :
- Complementary Index
- Journal :
- Obesity (19307381)
- Publication Type :
- Academic Journal
- Accession number :
- 125967530
- Full Text :
- https://doi.org/10.1002/oby.21984