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Ribociclib for post-menopausal women with HR+/HER2- advanced or metastatic breast cancer.
- Source :
- Expert Review of Clinical Pharmacology; Nov2017, Vol. 10 Issue 11, p1169-1176, 8p
- Publication Year :
- 2017
-
Abstract
- Introduction: The introduction of CDK4/6 inhibitors, such as ribociclib, has changed the treatment landscape for post-menopausal women with HR+/HER2- advanced or metastatic breast cancer. As first-line treatment of HR+/HER2- MBC, the addition of a CDK4/6 inhibitor to an aromatase inhibitor improves progression-free survival compared to an aromatase inhibitor alone. Areas covered: In this drug profile, we review the current market for HR+/HER2- MBC, as well as the characteristics, mechanism, pharmacology, pharmacodynamics, pharmacokinetics, metabolism, clinical efficacy, toxicities, monitoring, and dosing modification of the CDK4/6 inhibitor ribociclib. Expert commentary: CDK4/6 inhibitors, such as ribociclib, improve outcomes in post-menopausal women with HR+/HER2- MBC. The most common toxicity of ribociclib is neutropenia, which is generally not complicated and can be managed with dose modification and/or supportive care measures. Additional research will help better define the optimal clinical use of ribociclib. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17512433
- Volume :
- 10
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Expert Review of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 125829241
- Full Text :
- https://doi.org/10.1080/17512433.2017.1376653