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A Point System to Forecast Hepatocellular Carcinoma Risk Before and After Treatment Among Persons with Chronic Hepatitis C.
- Source :
- Digestive Diseases & Sciences; Nov2017, Vol. 62 Issue 11, p3221-3234, 14p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Risk of hepatocellular carcinoma (HCC) may be difficult to determine in the clinical setting.<bold>Aim: </bold>Develop a scoring system to forecast HCC risk among patients with chronic hepatitis C.<bold>Methods: </bold>Using data from the Chronic Hepatitis Cohort Study collected during 2005-2014, we derived HCC risk scores for males and females using an extended Cox model with aspartate aminotransferase-to-platelet ratio index (APRI) as a time-dependent variables and mean Kaplan-Meier survival functions from patient data at two study sites, and used data collected at two separate sites for external validation. For model calibration, we used the Greenwood-Nam-D'Agostino goodness-of-fit statistic to examine differences between predicted and observed risk.<bold>Results: </bold>Of 12,469 patients (1628 with a history of sustained viral response [SVR]), 504 developed HCC; median follow-up was 6 years. Final predictors in the model included age, alcohol abuse, interferon-based treatment response, and APRI. Point values, ranging from -3 to 14 (males) and -3 to 12 (females), were established using hazard ratios of the predictors aligned with 1-, 3-, and 5-year Kaplan-Meier survival probabilities of HCC. Discriminatory capacity was high (c-index 0.82 males and 0.84 females) and external calibration demonstrated no differences between predicted and observed HCC risk for 1-, 3-, and 5-year forecasts among males (all p values >0.97) and for 3- and 5-year risk among females (all p values >0.87).<bold>Conclusion: </bold>This scoring system, based on age, alcohol abuse history, treatment response, and APRI, can be used to forecast up to a 5-year risk of HCC among hepatitis C patients before and after SVR. [ABSTRACT FROM AUTHOR]
- Subjects :
- AGE distribution
ASPARTATE aminotransferase
BLOOD platelets
COMPARATIVE studies
DECISION making
CLINICAL pathology
ALCOHOL drinking
HEPATOCELLULAR carcinoma
LIVER tumors
RESEARCH methodology
MEDICAL cooperation
PROGNOSIS
RESEARCH
RESEARCH evaluation
RESEARCH funding
RISK assessment
TIME
EVALUATION research
PREDICTIVE tests
PROPORTIONAL hazards models
KAPLAN-Meier estimator
CHRONIC hepatitis C
PLATELET count
DISEASE complications
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 01632116
- Volume :
- 62
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Digestive Diseases & Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 125824878
- Full Text :
- https://doi.org/10.1007/s10620-017-4762-0