Back to Search
Start Over
Impact of Chronic Renal Failure on Safety and Effectiveness of Paclitaxel-Eluting Stents for Femoropopliteal Artery Disease: Subgroup Analysis from Zilver PTX Post-Market Surveillance Study in Japan.
- Source :
- CardioVascular & Interventional Radiology; Nov2017, Vol. 40 Issue 11, p1669-1677, 9p
- Publication Year :
- 2017
-
Abstract
- <bold>Purpose: </bold>Favorable long-term outcomes of the Zilver PTX drug-eluting stent (DES) in femoropopliteal lesions have been demonstrated. Chronic renal failure (CRF) has been shown to be a risk factor for restenosis and decreased limb salvage. The results of the DES in patients with CRF have not previously been reported. This study compares the results with the DES in patients with CRF and those without CRF.<bold>Methods: </bold>This retrospective analysis from the Zilver PTX Japan Post-Market Surveillance Study included 321 patients with CRF and 584 patients without CRF. Outcomes included freedom from target lesion revascularization (TLR) and patency.<bold>Results: </bold>Of the patients included in this subgroup analysis, 2-year data were available for 209 patients in the CRF group and 453 patients in the non-CRF group. The two groups were similar in terms of lesion length and the frequency of in-stent restenosis. Critical limb ischemia, severe calcification, and diabetes were more common in patients with CRF, whereas total occlusion was more common in patients without CRF. Freedom from TLR rates were 81.4 versus 84.9% (p = 0.24), and patency rates were 70.7 versus 70.3% (p = 0.95) in patients with and without CRF at 2 years, respectively.<bold>Conclusion: </bold>This is the first comparative study of the DES in femoropopliteal artery lesions in patients with and without CRF. These results indicate that the DES placed in femoropopliteal artery lesions of CRF patients is safe and effective with similar patency and TLR rates to patients without CRF.<bold>Level Of Evidence: </bold>Level 3, Post-Market Surveillance Study. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTINEOPLASTIC agents
PACLITAXEL
PERIPHERAL vascular disease treatment
CHRONIC kidney failure complications
CHRONIC kidney failure
COMPARATIVE studies
FEMORAL artery
LONGITUDINAL method
VASCULAR resistance
RESEARCH methodology
MEDICAL cooperation
PERIPHERAL vascular diseases
PROGNOSIS
RESEARCH
TIME
EVALUATION research
TREATMENT effectiveness
RETROSPECTIVE studies
POPLITEAL artery
DRUG-eluting stents
DISEASE complications
SURGERY
Subjects
Details
- Language :
- English
- ISSN :
- 01741551
- Volume :
- 40
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- CardioVascular & Interventional Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 125824768
- Full Text :
- https://doi.org/10.1007/s00270-017-1673-6