Back to Search
Start Over
Non-mix fragrances are top sensitizers in consecutive dermatitis patients - a cross-sectional study of the 26 EU-labelled fragrance allergens.
- Source :
- Contact Dermatitis (01051873); Nov2017, Vol. 77 Issue 5, p270-279, 10p
- Publication Year :
- 2017
-
Abstract
- Background For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of fragrance mix I ( FM I) and fragrance mix II ( FM II). Earlier reports have not included oxidized R-limonene [hydroperoxides of R-limonene ( Lim- OOH)] and oxidized linalool [hydroperoxides of linalool ( Lin- OOH)], and breakdown testing of FM I and FM II has mainly been performed in selected, mix-positive patients. Objectives To report the prevalence of sensitization to the 26 fragrances, and to assess concomitant reactivity to FM I and/or FM II. Methods A cross-sectional study on consecutive dermatitis patients patch tested with the 26 fragrances and the European baseline series from 2010 to 2015 at a single university clinic was performed. Results Of 6004 patients, 940 (15.7%, 95% CI: 14.7-16.6%) were fragrance-sensitized. Regarding the single fragrances, most patients were sensitized to Lin- OOH (3.9%), Evernia furfuracea (3.0%), Lim- OOH (2.5%), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (2.1%). Significantly fewer patients were ' FM I-positive and constituent-positive' than ' FM II-positive and constituent-positive' (32.7% versus 57.0%, p < 0.0001). Additionally, significantly more patients were ' FM II-negative but constituent-positive' than ' FM I-negative but constituent-positive' (12.4% versus 3.2%, p = 0.0008). Conclusions Non-mix fragrances are the most important single fragrance allergens among consecutive patients. The test concentration of the single FM I constituents should be increased when possible. [ABSTRACT FROM AUTHOR]
- Subjects :
- SKIN inflammation diagnosis
ALLERGENS
MEDICAL care
SENSITIZATION (Neuropsychology)
Subjects
Details
- Language :
- English
- ISSN :
- 01051873
- Volume :
- 77
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Contact Dermatitis (01051873)
- Publication Type :
- Academic Journal
- Accession number :
- 125820666
- Full Text :
- https://doi.org/10.1111/cod.12822