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Utility of soluble triggering receptor expressed on myeloid cells-I (sTREM-I) as biomarker to predict therapeutic response to methotrexate in rheumatoid arthritis.

Authors :
Gamez-Nava, Jorge I.
Bonilla-Lara, David
Ponce-Guarneros, Juan M.
Zuñiga-Mora, J. Alejandro
Perez-Guerrero, Edsaul E.
Murillo-Vazquez, Jessica D.
Becerra-Alvarado, Itzel N.
Rodriguez-Jimenez, N. Alejandra
Saldaña-Cruz, A. Miriam
Vazquez-Villegas, M. Luisa
Vera-Navarrete, Erika Y.
Gonzalez-Ponce, Fabiola
Gonzalez-Lopez, Laura
Source :
Innate Immunity; Oct2017, Vol. 23 Issue 7, p606-614, 9p
Publication Year :
2017

Abstract

The objective of this study was to investigate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in predicting short-term therapeutic response to methotrexate (MTX) in rheumatoid arthritis (RA). Patients with active RA, with Disease Activity Score-28 joints (DAS-28) >3.2, starting oral MTX, were included. We measured at baseline, 3 and 6 mo: DAS-28, Health Assessment Questionnaire-Disability Index (HAQ-DI), patient's perception of disease severity, morning stiffness and pain, as well as modifications in sTREM-1 levels. A reduction in DAS-28 > 1.2 at 3 or 6 mo was considered adequate response. A significant decrease in DAS-28 was observed at 3 and 6 mo. HAQ-DI also decreased at 3 and 6 mo. No significant changes were observed in sTREM-1 levels at 3 or 6 mo. Using as cut-off a baseline value of sTREM-1 levels > 390 pg/ml, we obtained low values of sensitivity (61.5%), specificity (59.3%), positive predictive value (59.3%) and negative predictive value (61.5%) for adequate response to MTX at 3 mo. We found no clinical value of sTREM-1 levels in predicting therapeutic response to MTX in RA. Further studies should evaluate if sTREM-1 levels are predictive for other outcomes, including higher structural damage or good response to biologics. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17534259
Volume :
23
Issue :
7
Database :
Complementary Index
Journal :
Innate Immunity
Publication Type :
Academic Journal
Accession number :
125730893
Full Text :
https://doi.org/10.1177/1753425917726862