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FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder.
- Source :
- Movement Disorders; Oct2017, Vol. 32 Issue 10, p1482-1486, 6p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder.<bold>Methods: </bold>In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent 18 F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included 18 F-fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD-related pattern expression z-scores were computed from all PET scans.<bold>Results: </bold>PD-related pattern expression was higher in idiopathic REM sleep behavior disorder subjects compared with controls (P = 0.048), but lower compared with PD (P = 0.001) and dementia with Lewy bodies (P < 0.0001). PD-related pattern expression was higher in idiopathic REM sleep behavior disorder subjects with hyposmia and in subjects with an abnormal dopamine transporter scan (P < 0.05, uncorrected).<bold>Conclusion: </bold>PD-related pattern expression, dopamine transporter binding, and olfaction may provide complementary information for predicting phenoconversion. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANALYSIS of variance
DEOXY sugars
DOPAMINE
LEWY body dementia
PARKINSON'S disease
PSYCHOLOGICAL tests
RADIOPHARMACEUTICALS
SLEEP disorders
SMELL disorders
POSITRON emission tomography
SINGLE-photon emission computed tomography
CROSS-sectional method
MEMBRANE transport proteins
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 08853185
- Volume :
- 32
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Movement Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 125690425
- Full Text :
- https://doi.org/10.1002/mds.27094