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Food elimination diets are effective for long-term treatment of adults with eosinophilic oesophagitis.
- Source :
- Alimentary Pharmacology & Therapeutics; Nov2017, Vol. 46 Issue 9, p836-844, 9p
- Publication Year :
- 2017
-
Abstract
- Background Limited data describe the long-term efficacy of dietary elimination in eosinophilic oesophagitis (EoE). Aim To assess the long-term outcomes of food elimination diets for treatment of adults with EoE. Methods We conducted a retrospective cohort study at our centre analysing all EoE patients receiving a food elimination diet without concomitant steroids. Baseline data were abstracted using standardised collection forms. Follow-up data from a mean 24.9-month period were collected for patients with a histological response to a food elimination diet during and after food reintroduction. The main outcomes were symptomatic, endoscopic and histological responses. Results Of 52 patients, 18 received a 6-food food elimination diet, 32 received targeted diet, and two received a 6-food food elimination diet with targeted elimination. There were 21 (40%) patients with an initial histological response. Responders reported less dysphagia after treatment (95% baseline vs 11%; P = .001) and at the end of follow-up (95% baseline vs 33%; P = .008). Significant and durable endoscopic improvements were recorded at the same time points: Endoscopic reference score: 3.2 vs 0.7; P = .001; and 3.2 vs 1.7; P = .06. Histological findings improved after the most restrictive diet in responders (49.8 vs 4.1 eosinophils per high-power field; P = .001) and remained suppressed in the 10 initial responders maintaining compliance at the end of follow-up (5.2 eosinophils per high-power field). Conclusions Among EoE patients responding to a food elimination diet and remaining adherent, maintenance dietary therapy produced durable long-term symptomatic, endoscopic and histological disease control. These long-term data confirm that a food elimination diet is an effective maintenance treatment option in select adults with EoE. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02692813
- Volume :
- 46
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Alimentary Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 125591849
- Full Text :
- https://doi.org/10.1111/apt.14290