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Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis.
- Source :
- Annals of Clinical & Translational Neurology; Oct2017, Vol. 4 Issue 10, p756-761, 6p
- Publication Year :
- 2017
-
Abstract
- Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis ( MS) and IgG levels in the cerebrospinal fluid ( CSF). However, how these variants are implicated in disease mechanisms remains unknown. Here, we show that proliferating plasmablasts expressing the G1m1 allotype of IgG1 are selectively enriched in CSF of G1m1/G1m3 heterozygous MS patients, whereas plasmablasts expressing either G1m1 or G1m3 are evenly distributed in blood. Moreover, there was a preferential intrathecal synthesis of oligoclonal IgG1 of the G1m1 allotype in heterozygous patients, whereas controls with Lyme neuroborreliosis displayed oligoclonal IgG1 of both allotypes. This points to a disease-specific mechanism involved in B-cell establishment within the central nervous system in MS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23289503
- Volume :
- 4
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Annals of Clinical & Translational Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 125581909
- Full Text :
- https://doi.org/10.1002/acn3.451