Association between immunoglobulin heavy-chain variable region mutational status and isolated favorable baseline genomic aberrations in chronic lymphocytic leukemia.

Immunoglobulin heavy-chain variable region (IGHV) mutational status and karyotype abnormalities are important prognostic factors in chronic lymphocytic leukemia (CLL). The goal was to assess the impact ofIGHVin CLL patients with isolated favorable genetic aberrations (del13q, trisomy 12, or negative fluorescencein situhybridization [FISH]). We studied 273 CLL patients with bothIGHVmutational status and cytogenetic information: 145 with isolated del13q 49 with sole trisomy 12 and 79 with negative FISH. After a median follow-up of 7.8 years, patients with del13q-unmutatedIGHVhad a shorter time to first treatment (TFT) (2.98 vs. 17.44 years;p < .001) and shorter overall survival (10.45 years vs. not reached;p = .0026). Patients with negative FISH-unmutatedIGHVhad shorter TFT (p = .02) (3.10 vs. 9.75 years,p = .053).IGHVstatus did not influence clinical outcomes in trisomy 12 CLL. In conclusion,IGHVmutational status shows prognostic impact in CLL patients with good prognosis genomic features. [ABSTRACT FROM AUTHOR]