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CXCL7 is a predictive marker of sunitinib efficacy in clear cell renal cell carcinomas.
- Source :
- British Journal of Cancer; 9/26/2017, Vol. 117 Issue 7, p947-953, 7p, 2 Charts, 3 Graphs
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Sunitinib is one of the first-line standard treatments for metastatic clear cell renal cell carcinoma (ccRCC) with a median time to progression shorter than 1 year. The objective is to discover predictive markers of response to adapt the treatment at diagnosis.<bold>Methods: </bold>Prospective phase 2 multi-centre trials were conducted in ccRCC patients initiating sunitinib (54 patients) or bevacizumab (45 patients) in the first-line metastatic setting (SUVEGIL and TORAVA trials). The plasmatic level of CXCL7 at baseline was correlated with progression-free survival (PFS).<bold>Results: </bold>The cut-off value of CXCL7 for PFS was 250 ng ml-1. Patients with CXCL7 plasmatic levels above the cut-off at baseline (250 ng ml-1) had a significantly longer PFS (hazard ratio 0.323 (95% confidence interval 0.147-0.707), P=0.001). These results were confirmed in a retrospective validation cohort. The levels of CXCL7 did not influence PFS of the bevacizumab-treated patients.<bold>Conclusions: </bold>CXCL7 may be considered as a predictive marker of sunitinib efficacy for ccRCC patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTINEOPLASTIC agents
HETEROCYCLIC compounds
INDOLE compounds
BLOOD proteins
CLINICAL trials
COMPARATIVE studies
GLOBULINS
KIDNEY tumors
KILLER cells
LONGITUDINAL method
LYMPHOCYTES
MACROPHAGES
RESEARCH methodology
MEDICAL cooperation
MICE
NEUTROPHILS
PROGNOSIS
RENAL cell carcinoma
RESEARCH
SURVIVAL
RAPAMYCIN
EVALUATION research
RETROSPECTIVE studies
NEPHRECTOMY
TUMOR grading
SURGERY
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 117
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 125350246
- Full Text :
- https://doi.org/10.1038/bjc.2017.276