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A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand.
- Source :
- Dalton Transactions: An International Journal of Inorganic Chemistry; 9/28/2017, Vol. 46 Issue 36, p12001-12004, 4p
- Publication Year :
- 2017
-
Abstract
- Esterification of (4-hydroxyphenyl)diphenylphosphine, coordinated to the [Ru(η<superscript>6</superscript>-p-cymene)Cl<subscript>2</subscript>] fragment, allows a series of bioactive carboxylic acids to be introduced directly into the organometallic molecule. Evaluation of the compounds on human ovarian cancer cells reveals synergistic enhancements in their antiproliferative activity relative to their bioactive organic and organometallic precursors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14779226
- Volume :
- 46
- Issue :
- 36
- Database :
- Complementary Index
- Journal :
- Dalton Transactions: An International Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 125231729
- Full Text :
- https://doi.org/10.1039/c7dt02062g