A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand.

Authors :: Biancalana, Lorenzo
Batchelor, Lucinda K.
De Palo, Alice
Zacchini, Stefano
Pampaloni, Guido
Dyson, Paul J.
Marchetti, Fabio
Source :: Dalton Transactions: An International Journal of Inorganic Chemistry; 9/28/2017, Vol. 46 Issue 36, p12001-12004, 4p
Publication Year :: 2017
Abstract: Esterification of (4-hydroxyphenyl)diphenylphosphine, coordinated to the [Ru(η<superscript>6</superscript>-p-cymene)Cl<subscript>2</subscript>] fragment, allows a series of bioactive carboxylic acids to be introduced directly into the organometallic molecule. Evaluation of the compounds on human ovarian cancer cells reveals synergistic enhancements in their antiproliferative activity relative to their bioactive organic and organometallic precursors. [ABSTRACT FROM AUTHOR]

Subjects :: ESTERIFICATION
RUTHENIUM compounds
BIOACTIVE compounds
LIGANDS (Chemistry)
CARBOXYLIC acids

Language :: English
ISSN :: 14779226
Volume :: 46
Issue :: 36
Database :: Complementary Index
Journal :: Dalton Transactions: An International Journal of Inorganic Chemistry
Publication Type :: Academic Journal
Accession number :: 125231729
Full Text :: https://doi.org/10.1039/c7dt02062g

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