Are non-pylori helicobacters present in the human oral cavity?

Introduction and objective: Helicobacter pylori ( H. pylori) is a human gastric pathogen. Because of presence of H. pylori oral cavity, there is a possibility of H. pylori transmission by oral-oral route. In a crosssectional study, the presence of some virulence factors of H. pylori and also non-pylori Helicobacters in dental plaque samples of participants was investigated. Methods: The samples were collected from at least two teeth surfaces. DNA of the samples was extracted using specific kit. The presence of dupA ( jhp0917 and jhp0918) and babA2 genes and also Helicobacter genus and H. pylori species was investigated using polymerase chain reaction by specific primers. Results: In total 44% (20/45) and 86.7% (39/45) of samples was positive for ureC and 16SrRNA genes respectively. The frequency of babA2, jhp0917 and jhp0918 genes in H. pylori isolates were 40, 20 and 65% respectively. It seems 19 samples were positive probably non-pylori Helicobacters. Conclusion: In the present study we report for the first time the presence of non- pylori Helicobacter species and also high frequency of babA2 and dupA genotypes in dental plaque samples. [ABSTRACT FROM AUTHOR]