Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail.

Authors :: Julg, Boris
Po-Ting Liu
Wagh, Kshitij
Fischer, William M.
Abbink, Peter
Mercado, Noe B.
Whitney, James B.
McMahan, Katherine
Tartaglia, Lawrence J.
Borducchi, Erica N.
Khatiwada, Shreeya
Kamath, Megha
LeSuer, Jake A.
Seaman, Michael S.
Schmidt, Stephen D.
Mascola, John R.
Burton, Dennis R.
Korber, Bette T.
Barouch, Dan H.
Source :: Science Translational Medicine; 9/20/2017, Vol. 9 Issue 408, p1-9, 9p
Publication Year :: 2017
Abstract: The article discusses a study related to exploration of single Broadly neutralizing antibodies (bNAbs) selection for resistant simian-HIV (SHIV) variants in prophylactic and therapeutic experiments in rhesus monkeys. It mentions single bNAbs efficiently select resistant viruses for establishing infection and demonstrating importance of bNAb cocktails for HIV-1 prevention and V3 glycan-dependent antibody PGT121 alone failing to protect against a mixed challenge with SHIV-SF162P3 and SHIV-325c.

Subjects :: IMMUNOGLOBULINS
SIMIAN immunodeficiency virus
RHESUS monkeys
HIV prevention
GLYCANS

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